ORIGINAL ARTICLE
Year : 2012  |  Volume : 11  |  Issue : 1  |  Page : 59-65

Bioactive lignans and other phenolics from the roots, leaves and seeds of Arctium lappa L. grown in Egypt


1 Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, Egypt
2 Department of Pharmacognosy, National Organization for Drug Control and Research, Cairo, Egypt
3 Department of Pharmacology, National Research Center, Giza, Egypt

Correspondence Address:
Elsayed A. Aboutabl
Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Kasr-el-Aini Str., 11562 Cairo
Egypt
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.7123/01.EPJ.0000415466.17860.6a

Rights and Permissions

Aim

Investigation of the phenolic constituents of roots, leaves and seeds of A. lappa L. cultivated in Egypt.

Methods

Qualitative and quantitative analysis of lignans and other phenolics by LC-MS/MS and HPLC/PDA-LC-MS/MS, as well as evaluation of potential bioactivities.

Results and conclusions

LC-MS/MS of the ethyl acetate fractions from Arctium lappa seeds, leaves and roots showed the presence of 13 phenolics, including lignans, distributed in the different organs. The following phenolics were identified: caffeic acid 1, genistein 2, biochanin A 3, luteolin 4, chlorogenic acid 5, materisenol 6, arctigenin 7, quercetin 8, cynarin 9, arctiin 10, lappaol A 11, rutin 12 and lappaol F 13. Quantification of these compounds by HPLC-PDA-MS/MS showed that arctiin was the major compound in seeds. The antioxidant, antihepatotoxic, anti-inflammatory and cytotoxic activities of ethanolic extracts of the different organs were evaluated.



[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1091    
    Printed30    
    Emailed0    
    PDF Downloaded204    
    Comments [Add]    

Recommend this journal