REVIEW ARTICLE
Year : 2013  |  Volume : 12  |  Issue : 1  |  Page : 1-10

D2M-dopaminergic receptor and 5-HT3 serotoninergic receptor antagonists having antiemetic profile


1 Department of Medicinal and Pharmaceutical Chemistry, Pharmaceutical and Drug Industries Research Division, National Research Centre, Giza, Egypt
2 Department of Medicinal and Pharmaceutical Chemistry, Pharmaceutical and Drug Industries Research Division, National Research Centre, Giza, Egypt; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
3 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt
4 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Misr University for Science &Technology, 6th of October City, Egypt

Correspondence Address:
Mohamed N. Aboul-Enein
Department of Medicinal and Pharmaceutical Chemistry, Pharmaceutical and Drug Industries Research Division, National Research Centre, 12622 Dokki, Giza, Egypt

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Source of Support: None, Conflict of Interest: None


DOI: 10.7123/01.EPJ.0000428875.20180.de

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Metoclopramide is the prototype of the orthopramide family and is used clinically as a stimulant of upper gastrointestinal motility and as an antiemetic. Its antiemetic potential is attributed mainly to the antagonist activity at D2-dopaminergic receptors in the chemoreceptor trigger zone of the central nervous system. Besides, ondansetron was the first selective 5-HT3 serotoninergic receptor antagonist used in clinics as an antiemetic. Herein, the antiemetic profile of different chemical classes of D2-dopaminergic receptor and 5-HT3 serotoninergic receptor antagonists will be discussed, which may be helpful in the development of potent antiemetic agents.



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