ORIGINAL ARTICLE
Year : 2013  |  Volume : 12  |  Issue : 2  |  Page : 148-154

Desmutagenic and antimutagenic potential of phenolics from Khaya grandifoliola (C.DC.), Meliaceae


1 Department of Pharmacognosy, National Research Centre, Dokki, Giza, Egypt
2 Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, Egypt
3 Department of Chemistry of Natural Compounds, National Research Centre, Dokki, Giza, Egypt
4 Department of Microbiology, National Research Centre, Dokki, Giza, Egypt
5 Department of Phytochemistry and Plant Systematics, National Research Centre, Dokki, Giza, Egypt

Correspondence Address:
Fatma A Hashem
Department of Pharmacognosy, National Research Centre, Elbehous street, 12311 Dokki, Giza
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1687-4315.124018

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Background and objectives Antimutagenic or protective effects have been attributed to many classes of phytocompounds, mainly flavonoids and phenolic compounds, present in foods. Anticancer, antioxidant and anti-inflammatory activities of Khaya spp. have been reported, but their desmutagenic and antimutagenic activities were not studied. The aim of this study was to identify the phenolic contents of Khaya grandifoliola and correlate the desmutagenic and antimutagenic activities of these compounds. Materials and methods Desmutagenic and antimutagenic activities of specimen extracts of K. grandifoliola leaves and flowers were evaluated by measuring the inhibition of Salmonella typhimurium TA100 His + revertants induced by ethyl methanesulphonate and ribose lysine. The phenolic contents of K. grandifoliola leaf extracts were determined using column and paper chromatography. Spectroscopic analysis UV, 1 H NMR, 13 C NMR and electrospray ionization were applied to identify the isolated compounds. Results and conclusion Five phenolic compounds were isolated for the first time from K. grandifoliola leaves. These compounds were identified as quercetin 3-O-rhamnoglucoside (rutin), quercetin 3-O-rhamnoside, quercetin 3-O-glucoside, quercetin and 6-methoxycoumarin-7-O arabinofuranoside. The alcoholic extracts of both leaves and flowers (total and successive) of K. grandifoliola, rutin and quercetin rhamnoside isolated from the leaves, exhibited desmutagenic and antimutagenic activity against ethyl methanesulphonate-induced and ribose lysine-induced reversion.


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