ORIGINAL ARTICLE
Year : 2014  |  Volume : 13  |  Issue : 2  |  Page : 144-150

Study of some biological activities of aqueous extract of ginger (Zingiber officinale)


1 Department of Chemistry of Natural and Microbial Products, National Research Center, Cairo, Egypt
2 Microbiology Department, Faculty of Science, Ain Shams University, Cairo, Egypt ; Biology Department, Faculty of Sciences, Tabuk University, Tabuk, Saudi Arabia

Correspondence Address:
Mohamed MI Helal
Department of Natural and Microbial Products Chemistry, National Research Centre, Dokki 12622, Cairo

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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1687-4315.147093

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Purpose This study was designed to evaluate the potential of two aqueous extracts of ginger rhizome under different extraction conditions (cold and hot water). Materials and methods Anticoagulant, fibrinolytic, antimicrobial, prebiotic, and antitumor activities were examined for the two aqueous extracts. The two aqueous extracts were then used for evaluation of yield, total carbohydrates, protein, and monosaccharide contents. The sulfation of crude extracts was carried out by chlorosulfonic acid as a sulfating agent in formamide. Results The results showed that sulfation modification of the two aqueous extracts increased significantly both the anticoagulation and the fibrinolytic activities, but did not affect the antimicrobial, prebiotic, or antitumor activities. However, the two native water extracts showed antibacterial activity against Escherichia coli only, but not for Staphylococcus aureus, and antifungal activity against Candida albicans. Conclusion The chemical modification of the two aqueous extracts of ginger by sulfation will increase significantly its anticoagulation and fibrinolytic activities while not affecting or improving the prebiotic and antimicrobial activities. However, the antitumor activity is high for both the native and the sulfated aqueous extracts of ginger. Thus, this result does not mean that the sulfation modification of the water extracts studied affected the antitumor activity.


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