ORIGINAL ARTICLE
Year : 2016  |  Volume : 15  |  Issue : 1  |  Page : 25-30

Pharmacological evaluation of Musa paradisiaca (Linn.) on bronchial asthma


1 Department of Pharmacology, College of Pharmaceutical Sciences, Berhampur, Odisha, India
2 Department of Pharmaceutics, Roland Institute of Pharmaceutical Sciences, Berhampur, Odisha, India
3 Department of Pharmacology, Maharaja Krushna Chandra Gajapati Medical College, Berhampur, Odisha, India

Correspondence Address:
Himanshu Bhusan Sahoo
Department of Pharmacology, Maharaja Krushna Chandra Gajapati Medical College, Berhampur - 760 004, Odisha
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1687-4315.184030

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Objective The present study was conducted to investigate the antiasthmatic potential from the flowers of Musa paradisiaca Linn. to validate its traditional claims. Materials and methods The antiasthmatic activity of the hydroalcoholic extract of M. paradisiaca flower (HMPF) was evaluated by studying histamine or acetylcholine-induced bronchospasm in guinea pigs, compound 48/80-induced mast cell degranulation in albino rats, and histamine-induced constriction in isolated guinea pig trachea. The preconvulsion dyspnea time at the 0th and seventh day at a dose of 200 and 400 mg/kg in guinea pigs, the percentage of granulated and degranulated mast cells at doses of 500, 750, and 1000 μg/ml in rats, and muscular contraction at doses of 500, 750, and 1000 μg/ml in isolated guinea pig trachea were evaluated and compared with their respective control groups. Results Phytochemical studies revealed the presence of flavonoids, steroids, saponin, terpenoids, lignins, and phenolic compounds in the extract. In addition, treatment with HMPF significantly (P < 0.001) decreased the bronchospasm induced by histamine or acetylcholine in guinea pigs, the degranulation of mast cell in rats, and histamine-induced constriction in isolated guinea pig trachea, when compared with the inducer group. In addition, HMPF showed a dose-dependent antiasthmatic effect in the animals. Conclusion The present study concluded that the antiasthmatic activity of the HMPF may be due to the presence of the above-mentioned phytoconstituents causing membrane stabilization, suppression of antibody production, and inhibition of antigen-induced histamine and acetylcholine.


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