ORIGINAL ARTICLE
Year : 2017  |  Volume : 16  |  Issue : 1  |  Page : 1-7

Hydrogen sulfide donors or related derivatives are the future medicines of renal diseases


Department of Pharmacology, College of Medicine, Al-Mustansiriya University, Baghdad, Iraq

Correspondence Address:
Marwan S.M. Al-Nimer
Professor of Pharmacology College of Medicine, Al-Mustansiriya University, P.O. Box 14132, Baghdad
Iraq
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1687-4315.205827

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Hydrogen sulfide (H2S) is one of the three gasotransmitters that possess anti-inflammatory, antiapoptotic, and antioxidant properties. It maintains the function of the kidney through its effect on the glomeruli and the renal transport system. Literature review using PubMed, Excerpta Medica database (EMBASE), Google scholar, and Cochrane review revealed that H2S donors are introduced as exogenous H2S and have been found to target many organs in in-vitro and in-vivo studies. This review provides the main research that was performed on the H2S donors in the context of kidney disease. Exogenous H2S supplementation can be administered in different therapeutic areas promising therapeutic strategy in the setting of kidney diseases. Therefore, suitable pharmaceutical preparations of H2S donors are necessary to be launched in the markets for the prevention and treatment of acute/chronic renal diseases.


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