ORIGINAL ARTICLE
Year : 2018  |  Volume : 17  |  Issue : 1  |  Page : 53-59

Cytotoxic activity of ketorolac-loaded chitosan nanoparticles in SCC-29 cell lines


1 Department of Pharmacy, Vaageswari College of Pharmacy, Telangana, India
2 Department of Pharmaceutical Chemistry, GITAM Institute of Pharmacy, GITAM (Deemed to be University), Rushikonda, Visakhapatnam, India

Correspondence Address:
Kola Venu
Vaageswari College of Pharmacy, Karimnagar, Telangana 505481
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/epj.epj_1_18

Rights and Permissions

Context Ketorolac (KT) is a NSAID, with multiple pharmacological activities having been reported. Aim To formulate chitosan nanoparticles of KT for assessing their potential in decreasing the growth of colon cancer cells. Materials and methods Chitosan nanoparticles of KT such as F1 and F2 have shown anticancer activity against SCC-29 cell lines. Furthermore, nanoparticles have been subjected to stability test at various pH, drug-release study, and in-vivo pharmacokinetics in Wistar rats. Results The nanoparticles were in the size range between 164 and 210 nm. The oral absorption of nanoparticles was relatively higher than the KT alone. Conclusion The prepared nanoparticle formulations showed better activity than KT alone.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed125    
    Printed4    
    Emailed0    
    PDF Downloaded34    
    Comments [Add]    

Recommend this journal