ORIGINAL ARTICLE
Year : 2018  |  Volume : 17  |  Issue : 2  |  Page : 104-108

Synthesis and biological activity of some new fused pyrazole-c-nucleosides


1 Chemistry of Natural and Microbial Products Department, National Research Center, Giza, Egypt
2 Department of Chemistry, Faculty of Science, El-Menoufia University, Shebin El-Koom, Egypt

Correspondence Address:
Samy A El-Assaly
Department of the Chemistry of Natural and Microbial Products, National Research Centre, 33 El Bohoth St, PO Box 12622, Dokki, Giza
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/epj.epj_4_18

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Background and objectives Owing to the high antiviral, antibiotic, antitumor, and antifungal activities associated with various C-nucleosides, much attention has been paid on the synthesis of this class of compounds. We synthesized new pyrazole-C-nucleosides through one-pot reaction of open sugar, phenyl hydrazine hydrochloride, and different bases in presence of acetic acid and sodium acetate as a catalyst. These nucleosides, containing pyrazole moiety, have been marked as biologically active compounds.


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