ORIGINAL ARTICLE
Year : 2020  |  Volume : 19  |  Issue : 2  |  Page : 113-123

Synthesis, antioxidant, anticoagulant, and fibrinolytic activities of new isatin derivative


1 Department of Chemistry of Natural and Microbial Products, Pharmaceutical and Drug Industries Research Division, National Research Centre, Dokki, Cairo, Egypt
2 Department of Therapeutic Chemistry, Pharmaceutical and Drug Industries Research Division, National Research Centre, Dokki, Cairo, Egypt

Correspondence Address:
Assistant Professor (PhD) Weam S El-Serwy
Department of Chemistry of Natural and Microbial Products, Pharmaceutical and Drug Industries Research Division, National Research Centre, Dokki, Cairo 12622
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/epj.epj_52_19

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Background Isatin as a product was first obtained from the oxidation of indigo dye by nitric acid and chromic acids by Otto Linné Erdman and Auguste Laurent in 1841. Objective This study presents the synthesis of some new isatin derivatives and examines their biological activities. Materials and methods 2-Cyano-N’-(5-nitro-2-oxoindolin-3-ylidene)acetohydrazide (2) reacted with some reagents, namely, salicylaldehyde, phenyl isothiocyanate, ethyl chloroacetate, ethyl iodide, ethyl cyanoacetate, thioglycolic acid, phenyl isothiocyanate, malononitrile, and hydrazine hydrate to produce compounds 3, 4, 5, 6, 8, 9, 10, 11, and 12, respectively. Moreover, compound 6 reacted with hydrazine hydrate to produce compound 7. Antimicrobial activities of some newly synthesized compounds were studied. Results Antioxidant, anticoagulant, and fibrinolytic activities of the new synthesized compounds (1–12) were studied. Compound 10 exhibited highest fibrinolytic activity. On the contrary, compound 12 exhibited highest anticoagulant activities. Moreover, it was noticed that compound 9 exhibited highest antioxidant activity. Conclusion In summary, 14 novel isatin derivatives were synthesized and screened for their antioxidant, anticoagulant, and fibrinolytic activities. Some compounds displayed moderate-to-excellent activities such as antioxidant, anticoagulant, and fibrinolytic agents.


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