ORIGINAL ARTICLE
Year : 2020  |  Volume : 19  |  Issue : 2  |  Page : 172-181

Green synthesis and biological screening of some fluorinated pyrazole chalcones in search of potent anti-inflammatory and analgesic agents


1 Organic Chemistry Research Laboratory, Department of Chemistry, DBF Dayanand College of Arts & Science, Solapur, India
2 Organic Chemistry Research Laboratory, School of Chemical Sciences, P.A.H. Solapur University, Solapur, India
3 Department of Pharmaceutical Chemistry, DKSS’s Dattakala College of Pharmacy, Swami Chincholi, Pune, Maharashtra, India

Correspondence Address:
MSc, PhD Shravan Y Jadhav
Department of Chemistry, DBF Dayanand College of Arts & Science, Solapur 413002, Maharashtra
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/epj.epj_64_19

Rights and Permissions

Background and objective Fluorinated pyrazoles are widely studied for their anti-inflammatory activities. A new series of fluorinated pyrazole chalcones (4a-g and 5a-g) were synthesized and screened for anti-inflammatory and analgesic activities. Materials and methods Fluorinated pyrazole chalcones were synthesized using polyethylene glycol 400 (PEG-400) as an alternative reaction medium. The anti-inflammatory activity of compounds 4a-g and 5a-g were assessed by the carrageenan paw edema model in rats. Analgesic activity was studied by the tail-flick method in rats. Result and conclusion Among the series, compound 5f was found to be the most potent anti-inflammatory agent, whereas compounds 4c, 4f, 4g, 5a, 5c, 5d, and 5g showed significant anti-inflammatory activity comparable to the reference standard diclofenac sodium. Three compounds 4d, 4f, and 5c showed significant analgesic activity comparable to the reference standard aspirin. From the result, compounds 4c, 4f, 5a, 5c, and 5f have found biologically active members with an interesting dual anti-inflammatory and analgesic profile. Anti-inflammatory activities are supported by the docking study to analyze the possible interactions with the cyclooxygenase-2 enzyme.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed109    
    Printed2    
    Emailed0    
    PDF Downloaded42    
    Comments [Add]    

Recommend this journal